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May 2013 Researcher of the Month - Xiangmei Xi, PhD

Xiangmei Xi, PhDCurrent Studies
I joined the Diabetes Research Program to study the molecular and cellular mechanisms of diabetes-related complications such as ischemia and atherosclerosis. Interactions between the Receptor for Advanced Glycation Endproducts (RAGE) and its ligands were shown to affect pro-inflammatory gene (MCP-1/CCL2) expression.  Earlier discoveries from this group show that stress-induced up-regulation of Egr-1 requires RAGE signaling and mDia1. 

My research goal is to decipher the correlation between RAGE signaling and inflammation which may lead to the discovery of novel therapeutic targets for preventing or reversing diabetic complications.

 

Publications
1.  Xi X, Persson L, Mohr I and Wilson AC. Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpes virus lytic promoters.  Journal of Virology (2012) Jan; 86(2): 1021-33.

2.  Xi X, Sun Y, Karim CB, Grigoryants VM and Scholes CP.  HIV-1 Nucleocapsid Protein NCp7 and its RNA Stem Loop 3 Partner:  Rotational Dynamics of Spin-Labeled RNA Stem-Loop 3.  Biochemistry (2008) 47, 10099-10110. 

3.  Zhang Z, Xi X, Scholes CP and Karim CB.  To appear as the highlighted Research Highlights Article "Rotational Dynamics of HIV-1 Nucleocapsid Protein NCp7 as Probed by a Spin Label Attached by Peptide Synthesis.  Biopolymers (2008) 89, 1125-1135. 

 

Oral presentations
Xiangmei Xi
, Linda Persson, Ian Mohr and Angus Wilson.  Student and Postdoc Work in progress (WIPS), Department of Microbiology, New York University Medical Center.  July 13th 2011, “Viral interferon regulatory factor 4 (vIRF4) & cellular caspases modulate RTA dependent expression of KSHV lytic genes.”

Xiangmei Xi, Linda Persson, Ian Mohr and Angus Wilson.  18th Symposium on Virus-Host Interactions. December 7th 2010, The House of the Redeemer, New York, NY.  “Viral interferon regulatory factor 4 (vIRF4) & caspases modulate RTA dependent expression of KSHV lytic genes.”

Xiangmei Xi and Nicholas Conrad.  RNA Club, University of Texas, Southwestern Medical Center, Feb 24th 2009, Dallas, TX. “Identification of cellular factors that interact with Kaposi’s Sarcoma associated Herpesvirus protein ORF57.”

 

Poster Presentations in Symposiums and Conferences
Xiangmei Xi
, Linda Persson, Ian Mohr and Angus Wilson.  Department of Microbiology and Pathology retreat, New York University School of Medicine, Nov 6th 2010, Cold Spring Harbor, New York, NY. “Viral interferon regulatory factor 4 (vIRF4) & cellular caspases modulate RTA dependent expression of KSHV lytic genes”.

Xiangmei Xi and Nicholas Conrad.  Department of Microbiology retreat, University of Texas, Southwestern Medical Center, April 19th 2008, Dallas, TX. “Identification of cellular factors that interact with Kaposi’s Sarcoma associated Herpesvirus protein ORF57”.

Xi X, Karin, CB, Grigoryants VM, and Scholes CP. Poster Presentation B99 at Biophysical Society Annual Meeting, February 12-16, 2005, Long Beach, CA.  “The Mutual Folding of Retroviral Stem Loop RNA and HIV Nucleocapsid Protein NCP7.”

Scholes CP, Karim CB, Xi X, Sun Y, Grigoryants VM, and Zhang Z.  Poster Presentation at 31st Electron Paramagnetic Resonance (EPR) Symposium at the 50th Rocky Mountain Conference on Analytical Chemistry July 27-31 2008, Beaver Run, CO.  ”HIV-1 Nucleocapsid Protein NCp7 and Its Interacting RNA-Stem Loop Partner:  Rotational Dynamics of Spin-Labeled RNA-Stem Loop 3 and Spin-Labeled NCp7”.

Karim CB, Xi X, Grigoryants VM and Scholes CP.  Poster Presentation at Fifth
International Retroviral Symposium, September 18-20, 2005, Montreal, Canada.  “Dynamics of the HIV-1 Nucleocapsid Protein/RNA Complex as a Function of the Ionic Strength.”

 

Future Plans
It is my goal to merge my knowledge and expertise in the mechanistic study of RAGE signaling pathway and inflammation with the goal of novel therapeutic development for diabetes complications and atherosclerosis. 

Additionally, it’s always a pleasure for me to share my scientific knowledge by teaching others.  So, my long term plan is to become a scientific educator.