Md Khursheed, PhD, Postdoctoral Fellow

Md Khursheed, PhDI received my PhD from the Centre for DNA Fingerprinting and Diagnostics (CDFD) in Hyderabad, India. My PhD thesis* was titled “Identification and functional characterization of novel pancreatic cancer gene(s)”.

During my studies, I characterized two frequent novel homozygous deletions located at 6q25.3 and 18q23 in pancreatic cancer and functionally characterized two novel tumor suppressor genes, ARID1B (component of SWI/SNF chromatin remodeling complex) and PARD6G (component of PAR polarity complex) in pancreatic cancer.

I joined the Diabetes Research Program in 2013.  One of my goals is to enhance my understanding of the receptor for advanced glycation end products (RAGE) mediated signaling mechanism in diabetic complications and inflammatory conditions during ischemia and reperfusion process using in vitro and in vivo models.


Publications:
1.  Md Khursheed, Kolla JN, Kotapalli V, Gupta N, Gowrishankar S, Uppin SG, Sastry R, Koganti S, Sundaram C, Pollack JR, Bashyam MD. ARID1B, a member of the human SWI/SNF chromatin remodeling complex, exhibits tumor suppressor activities in pancreatic cancer cell lines. British Journal of Cancer, 2013, 108:2056-2062.

2. Md Khursheed and Bashyam MD. Apico-basal polarity complex and cancer. J. Biosci. 39(1), March 2014, 145–155.

* Thesis titled: “Identification and functional characterization of novel pancreatic cancer gene(s)” published in University Grants Commission (UGC), Govt. of India national research thesis database “Shodhganga”.  http://shodhganga.inflibnet.ac.in/handle/10603/11669