Michaele Manigrasso, PhD, Postdoctoral Fellow

Michaele Manigrasso, PhD

I graduated from Syracuse University with a degree Bioengineering. I received my joint PhD from Rutgers University (New Brunswick, NJ) and the University of Medicine and Dentistry School (UMDNJ-NJMS, Newark, NJ) in Biomedical Engineering. My graduate studies focused on the identification of arachidonic acid metabolites as key regulatory pathway in bone regeneration using a novel mouse fracture model. 

Following my PhD, I completed a JDRF-funded postdoctoral fellowship at The University of Mississippi Medical Center in the Department of Physiology and Biophysics where I concentrated on examining the role of androgens and estrogens in the development and progression of type 1 diabetic renal disease.
After the completion of this fellowship, I decided to continue my work in diabetic renal disease and joined the Diabetes Research Program at NYU in to September 2012 under the mentorship of Dr. Ann Marie Schmidt.

I hope to combine my previous research examining gender in diabetes with my current project at NYU to explore the role of RAGE and inflammation in the pathogenesis of type1 diabetes in both males and females. Most importantly, the training that I continue to receive through pursuing these studies will contribute to my development into an independent investigator dedicated to research for finding the cure of end-organ complications associated with type 1 diabetes.
 

Publications
1.  Manigrasso MB. Diabetes and vascular disease: sex matters. Vascular Pharmacology 2012; 57(2-4): 78-80.

2.  Maric-Bilkan C and Manigrasso MB. Sex differences in hypertension: contribution of the renin-angiotensin system. Gender Medicine 2012; 9(4):287-91.

3.  Manigrasso MB, Sawyer RT, Hutchens ZM Jr, Flynn ER, Maric-Bilkan C.  Combined inhibition of aromatase activity and dihydrotestosterone supplementation attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats. Am J Physiol-Renal Physiol 2012; 302(9):F1203-09.

4.  Barsony J, Manigrasso MB, Xu Q, Tam H, Verbalis JG.  Chronic hyponatremia exacerbates multiple manifestations of senescence in male rats. AGE (Dordr) 2012; Epub ahead of print.

5.  Manigrasso MB, Sawyer RT, Marbury DC, Flynn ER, Maric C. Inhibition of estradiol synthesis attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats. Am J Physiol-Renal Physiol 2011; 301(3):F634-40.

6.  Liu J, Sharma N, Zheng W, Ji H, Tam H, Wu X, Manigrasso MB, Sandberg K, Verbalis JG.  Sex differences in vasopressin V2 receptor expression and vasopressin-induced antidiuresis. Am J Physiol-Renal Physiol 2011; 300(2):F433-40.

7.  Manigrasso MB, O’Connor JP.  Accelerated fracture healing in mice lacking the 5- lipoxygenase gene. Acta Orthopaedica 2010; 81(6):748-755.

8.  Venegas-Pont M, Manigrasso MB, Grifoni SC, Lamarca BB, Maric C, Racusen LC, Glover PH, Jones AV, Drummond HA, Ryan MJ. Tumor necrosis factor-{alpha} antagonist etanercept decreases blood pressure and protects the kidney in a mouse model of systemic lupus erythematosus. Hypertension 2010; 56(4):643-649.

9.   A, Xu Q, Manigrasso MB, Biswas M, Flynn E, Iliescu R, Lephart ED, Maric C.  Expression of aromatase, androgen and estrogen receptors in peripheral target tissues in diabetes.  Steroids 2010; 75(11):779-787.

10.  O’Connor JP, Capo JT, Tan V, Cottrell JA, Manigrasso MB, Bontempo N, Parsons JR.  A comparison of Ibuprofen and rofecoxib effects on rabbit fibula osteotomy healing.  Acta Orthopaedica 2009; 80(5):597-605.

11.  Xu Q, Prabhu A, Xu S, Manigrasso MB, Maric C.  Dose-dependent effects of dihydrotestosterone in the streptozotocin-induced diabetic rat kidney. Am J Physiol-Renal Physiol 2009; 297(2):F307-315.

12.  Capo JT, Kinchelow T, Brooks K, Tan V, Manigrasso M, Francisco K.  Biomechanical stability of four fixation constructs for distal radius fractures.  Hand (NY) 2009; 4(3):272-278.

13.  Garman JH, Mulroney S, Manigrasso M, Flynn E, Maric, C.  Omega-3 fatty acid rich diet prevents diabetic renal disease.  Am J Physiol-Renal Physiol 2009; 296(2): F306-316.

14.  Manigrasso MB, O’Connor JP.  Comparison of fracture healing among different inbred mouse strains.  Calcif Tissue Int. 2008; 82(6): 465-474.

15.  Manigrasso MB, O’Connor JP.  Characterization of a closed femur fracture model in mice.  J. Orthop Trauma 2004; 18(10): 687-695.

16.  Simon AM, Manigrasso MB, O’Connor JP.  Cyclo-oxygenase 2 function is essential for bone fracture healing.  J Bone Miner Res 2002; 17(6):963-976.